Intense researcher turns administrator

Prof. Surya Satyanarayana Singh by training has a Master of Science degree in Biochemistry from Osmania University. His passion for research and love for imparting knowledge earned him an appointment in the same University after graduation 1988 as an Assistant Professor in the Department of Biochemistry. By dint of hard work, Prof. Singh enrolled in a Ph.D. programme in the same department where he combined his teaching and research work.

His Ph.D. research work provided him an opportunity for a post-doctoral research with the New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA where he worked for 4years. While in the US, his research work centred on the role of Phosphatidylinositol 3-kinase and Protein kinase C isozymes in Signal Transduction.
On his return from the US in 1996, Prof. Singh was promoted to a full professor status and has been with the Biochemistry Department since.

About his personal achievements, Prof. Singh has won very prestigious awards which include the Young Investigator Award from American Society for Neurochemistry, March 1995. The Travel Award from ASN to attend 24th Annual meeting at Richmond, Virginia, USA. 1993 and the Council of Industrial Research, JRF Award 1985-87, & SRF in 1987-1989 to pursue Ph.D. research work.

His research focus has been on new tumor suppressor genes (profiling) and hypoxia (HIF1-α) associated ailments such as dementia and cancer which he has carried out using state of art techniques for the past 20 years. His concentrations has been in the areas of Signal Transduction by Protein kinases, Phosphoinositides, PI3-kinase, PKC etc, Molecular Biology which involves cloning and profiling I and II isoforms as GST and his tagged fusion protein and their expression and purification to identify their role in tumor invasion.

Prof. Singh is also pursuing research in Tumor markers profiling, Hypoxia which is a neuronal proteome analysis under hypoxic conditions and role in dementia, transient transfection studies using neuronal cell lines and analysis of mechanism of HIF stabilization, Raising polyclonal antibodies to proteins and peptides, purification and titer determination and subsequent uses (with ELISA, Western Blotting, Immunohistochemistry etc.), Protein – protein interactions (profiling and protein interactions in breast cancer, using 2D electrophoresis and peptide fingerprinting and de novo sequencing using LCMS) and Cytokine analysis (analysis of cytokines under septic shock using Real Time PCR).

His administrative experience ramges from membership on several important boards to chairing very key committees in and outside Osmania University. As a professor of biochemistry, Prof. Singh has worked as the Head of Department from 2007 till date and has supervised nineteen Ph.D. scholars who have received their awards and currently supervising four Ph.D. all of whom have worked in the areas of Biochemistry, Nutrition and Pharmacy. He has also worked on several funded projects which has seen him manage crores of rupees from both government and private organisations.

As an academic, he has about 47 publications to his credit some of which are co-authored. He has presented conference papers most significant is a conference paper presented on the non-invasive technique to predict the mutagenicity and teratogenicity using onions.

He also has to his credit a patent filed titled; β-N-oxalyl-L-α,β-diaminopropionic acid (L-ODAP), also known as BOAA, (β-N-oxalylamino-L-alanine) the natural compound present in Lathyrus sativus (Kesari dhal) is pro angiogenic and aids in wound healing. J.O.G.

Prof. Singh co-edited the book titled “Mechanisms of Toxicity” published in 1996 and contributed a chapter to the book “Cellular Signaling and Apoptosis Research” by Alex R. Demasi Publishers- Nova Science Publishers, USA 2007 on Profilin: From Allergen to Tumor Suppressor; pp. 159-184 (Surya S. Singh, K.V.N. Radhika and Wasia Rizwani et al., Osmania Univ., India) ub. Date: 2007

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